The safest locations in low security space are in the middle of nowhere. If all gates are being monitored and there are no Stations with Sentry guns to retreat to, bookmark a few locations while in warp, and then warp back to one of your bookmarks. Sit it out there but be ready to warp to another of the bookmarks if anyone finds you.
If you are mining in low security space, align your ship with your warp out destination, this saves you time turning your ship when you need to make a fast getaway. Handy if you are in a battleship with a turning circle like a brick on ice.
When cloaked and stationary at a hostile gate, hit MWD (microwarp drive) set to manual for a 10 second burn; by the time you come uncloaked and hit your destination, the last bit of MWD will spin you around and get  Eve Isk you into warp a lot faster.
To make a good safe spot, click on add bookmark in your places folder while in warp, then find that bookmark before you come out of warp and go to it.
Find another spot off that track to warp to and do the bookmark thing again .This will place you between 3 points and make you very hard to find. Keep your clones up to date!
Ensure that your autopilot is always set with a location in a different system. That way you can get to Warp (and away from danger) very quickly by just clicking the engage Autopilot button.
TREAT EVERYONE AS HOSTILE unless you know otherwise, i.e. if you don't know someone as a friend or acquaintance assume they are planning to kill you and watch them at all times.